Fig. 1 · Structure
Documents & Downloads
NTE-122 dihydrochloride
Acyltransferase Inhibitor
NTE-122 dihydrochloride is a potent inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT), demonstrating an IC50 of 7.6 nM in liver and 4.4 nM in aorta tissues of cholesterol-fed rabbits. This compound is significant for research into atherosclerosis, as it modulates cholesterol esterification processes, potentially impacting lipid metabolism and cardiovascular health. Its application may provide insights into therapeutic strategies for managing atherosclerotic diseases.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 166967-84-6 |
| Applications | Acyltransferase Inhibitor |
| Formula | C38H60Cl2N6O2 |
| Molecular Weight | 703.83 |
| SMILES | CN(C)C(C=C1)=CC=C1NC(N(C2CCCCC2)C[C@@H](CC3)CC[C@H]3CN(C4CCCCC4)C(NC5=CC=C(C=C5)N(C)C)=O)=O.Cl.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.