Fig. 1 · Structure
Documents & Downloads
nTRD22
RNA-binding Allosteric Regulator
nTRD22 is an RNA-binding allosteric regulator that targets TDP-43. By binding to the N-terminal domain of TDP-43, nTRD22 modulates the RNA-binding domain, ultimately diminishing its RNA-binding capacity. This compound has been shown to decrease TDP-43 protein levels in primary motor neurons and alleviate motor dysfunction in models of amyotrophic lateral sclerosis. nTRD22 is suitable for research focusing on the pathophysiology and therapeutic strategies related to amyotrophic lateral sclerosis.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1065567-62-5 |
| Applications | RNA-binding Allosteric Regulator |
| Formula | C19H22F3N3O4 |
| Molecular Weight | 413.39 |
| SMILES | O=C(C1=NOC(COC2=CC=CC(C(F)(F)F)=C2)=C1)NCCN3CCCC(C3)O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.