NTRK Degrader-1 is a potent PROTAC degrader specifically targeting both wild-type and mutant NTRK1, with IC50 values of 4 nM for wild-type, 2 nM for G595R, 5 nM for G667C, and <0.5 nM for F598L. This compound induces ubiquitination and subsequent proteasomal degradation of NTRK1 variants, making it a valuable tool for studying NTRK-mediated signaling pathways. NTRK Degrader-1 is particularly useful in research focused on solid tumors associated with NTRK1 dysregulation.
Fig. 1 · Structure
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NTRK degrader-1
NTRK1 Degrader
NTRK Degrader-1 is a potent PROTAC degrader specifically targeting both wild-type and mutant NTRK1, with IC50 values of 4 nM for wild-type, 2 nM for G595R, 5 nM for G667C, and <0.5 nM for F598L. This compound induces ubiquitination and subsequent proteasomal degradation of NTRK1 variants, making it a valuable tool for studying NTRK-mediated signaling pathways. NTRK Degrader-1 is particularly useful in research focused on solid tumors associated with NTRK1 dysregulation.
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Biological Activity
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Degrader |
| CAS Number | 2922274-35-7 |
| Applications | NTRK1 Degrader |
| Formula | C38H35FN10O6 |
| Molecular Weight | 746.75 |
| SMILES | O=C1NC(C=CC(C(NCC(N2CCN(C3=CC=C(NC4CCC(NC4=O)=O)C=C3)CC2)=O)=O)=C5)=C5OC(C=CC(F)=C6)=C6CNC7=NC8=C1C=NN8C=C7 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.