Fig. 1 · Structure
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Nurr1 agonist 2
Nurr1 Agonist
Nurr1 Agonist 2 is an effective Nurr1 agonist with an EC50 of 0.07 μM, demonstrating high affinity for the recombinant Nurr1 ligand binding domain with a Kd of 0.14 μM. This compound enhances the expression of Nurr1-regulated genes, specifically increasing mRNA levels of tyrosine hydroxylase (TH) and vesicular amino acid transporter 2 (VMAT2). It serves as a valuable tool for research applications focused on neurobiology and the study of dopaminergic signaling pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 742058-34-0 |
| Applications | Nurr1 Agonist |
| Formula | C18H14O3S |
| Molecular Weight | 310.37 |
| SMILES | OC(C1=CC=C(C2=CC=C(C=C2)OCC3=CC=CC=C3)S1)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.