Fig. 1 · Structure
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Nusinersen
SMN Inducer
Nusinersen is an antisense oligonucleotide that targets the SMN2 gene to enhance pre-messenger RNA splicing. By promoting the production of full-length survival motor neuron (SMN) protein, Nusinersen plays a crucial role in the treatment of spinal muscular atrophy (SMA). This compound is valuable in research focused on genetic disorders related to neuronal degeneration and SMN protein deficiency.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inducer |
| CAS Number | 1258984-36-9 |
| Applications | SMN Inducer |
| Molecular Weight | 7127.30 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.