Fig. 1 · Structure
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NV03
UHRF1-H3K9me2/3 Interaction Antagonist
NV03 is a selective antagonist of the Ubiquitin-like with PHD and RING finger domains 1 (UHRF1)-H3K9me3 interaction, acting through binding to the UHRF1 tandem Tudor domain, with a dissociation constant (Kd) of 2.4 μM. Additionally, NV03 serves as a ligand for E3 ligases, making it a valuable tool in studies related to ubiquitination processes. This compound is primarily utilized in anticancer research, providing insights into chromatin regulation and potential therapeutic strategies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 2448341-58-8 |
| Applications | UHRF1-H3K9me2/3 Interaction Antagonist |
| Formula | C19H27N5O2S |
| Molecular Weight | 389.51 |
| SMILES | O=C1N(CC(NCCCN(CC)CC)=O)N=C(C)N2C1=C(C)C3=C2C=CS3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.