Documents & Downloads

NVP-BQS481

Eg5 Inhibitor

NVP-BQS481 is a potent inhibitor of Kinesin spindle protein-5 (Eg5), exhibiting an IC50 of less than 0.5 nM. This compound demonstrates significant antimitotic and antitumor activity, with an IC50 of 0.9 nM against SK-OV-3ip cancer cells. NVP-BQS481 is suitable for use as a cytotoxic payload in the development of antibody-drug conjugates (ADCs), making it a valuable tool for cancer research and therapeutic applications.

Out of Stock

Free Aliquoting for Your Order

Tell us your preferred amount per vial. We’ll confirm the options.

Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	1161925-41-2
Applications	Eg5 Inhibitor
Formula	C₂₇H₃₃F₃N₄O₂
Molecular Weight	502.57
SMILES	FC[C@@H](N)CCN(C(CO)=O)[C@H](C(C)(C)C)C1=NC(C2=C(F)C=CC(F)=C2)=CN1CC3=CC=CC=C3

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.