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NVP-QBE170

ENaC Inhibitor

NVP-QBE170 is a selective inhibitor of the Epithelial Sodium Channel (ENaC), demonstrating an IC50 value of 57.5 nM. It effectively modulates ENaC activity in human bronchial epithelial cells (HBECs) and exhibits prolonged action. In guinea pig models, NVP-QBE170 significantly reduces ENaC activity in the airways, highlighting its potential in studies related to hyperkalaemia. This compound is a valuable tool for researchers investigating ENaC-related physiological and pathophysiological processes.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	1080018-61-6
Applications	ENaC Inhibitor
Formula	C₃₀H₃₆Cl₂N₁₆O₄
Molecular Weight	755.62
SMILES	O=C(C1=NC(Cl)=C(N)N=C1N)NC(NC2CCN(CC2)C(C3=CC=C(C(N4CCC(CC4)NC(NC(C5=NC(Cl)=C(N)N=C5N)=O)=N)=O)C=C3)=O)=N

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.