Fig. 1 · Structure
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NVP-SAA164
Kinin B1 Receptor Antagonist
NVP-SAA164 is a nonpeptide antagonist targeting the kinin B1 receptor, demonstrating oral bioactivity. This compound effectively reverses mechanical hyperalgesia induced by Complete Freund's adjuvant and desArg10KD in human B1 receptor knock-in mice. Additionally, it exhibits inactivity in models of inflammatory pain in wild-type mice, making it a valuable reagent for research into pain mechanisms and therapeutic interventions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 312722-60-4 |
| Applications | Kinin B1 Receptor Antagonist |
| Formula | C36H45N5O5S |
| Molecular Weight | 659.84 |
| SMILES | O=C(N1CCOCC1)C2=CC(S(=O)(N3CCC(CC3)C(N4CCN(CC4)C)=O)=O)=CC=C2NCC(C5=CC=CC=C5)C6=CC=CC=C6 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.