Fig. 1 · Structure
Documents & Downloads
NVS-ZP7-4
ZIP7 Inhibitor
NVS-ZP7-4 is a specific inhibitor of the zinc transporter SLC39A7 (ZIP7), effectively modulating intracellular zinc levels. This compound plays a pivotal role in the Notch signaling pathway and is involved in the regulation of ferroptosis. NVS-ZP7-4 induces endoplasmic reticulum (ER) stress and demonstrates the capacity to inhibit ferroptosis, particularly mitigating Erastin-induced cytotoxicity in cellular models. Its applications extend to studies of cellular stress responses and ferroptosis mechanisms, making it a valuable tool for research in cancer and neurodegenerative diseases.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2349367-89-9 |
| Applications | ZIP7 Inhibitor |
| Formula | C28H28FN5OS |
| Molecular Weight | 501.62 |
| SMILES | O=C(NC12CCN(C[C@@H](NC3=NC4=CC=C(F)C=C4S3)CC5=CC=CC=C5)CC2)NC6=C1C=CC=C6 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.