Fig. 1 · Structure
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NW 1028
VCP/p97 Inhibitor
NW 1028 is a selective inhibitor of VCP/p97, targeting the ND1L domain to effectively block p97-dependent protein degradation. With Kd values of 100 nM for the ND1L domain and 285 nM for full-length p97, NW 1028 demonstrates strong binding affinity. This compound plays a crucial role in regulating the mitotic spindle, making it valuable for research in cell division and related fields.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2749599-78-6 |
| Applications | VCP/p97 Inhibitor |
| Formula | C19H21N5O4S |
| Molecular Weight | 415.47 |
| SMILES | O=C(C1=CC(NC(N2)=S)=C(C=C1)C2=O)N3[C@H](C(N4[C@H](C(N)=O)CCC4)=O)CCC3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.