NXT629

Catalog No.: A18771

PPAR-α antagonist

NXT629

NXT629 Chemical Structure

CAS NO. 1454925-59-7

NXT629 is a potent, selective, and competitive PPAR-α antagonist, with an IC50 of 77 nM for human PPARα, shows high selectivity over other nuclear hormone receptor, such as PPARδ, PPARγ, ERβ, GR and TRβ, IC50s are 6.0, 15, 15.2, 32.5 and >100 μM, respectively.

Availability: In stock

Package Price Qty
1 mg

Regular Price: $180.00

Special Price $144.00

5 mg

Regular Price: $600.00

Special Price $480.00

10 mg

Regular Price: $880.00

Special Price $704.00

50 mg

Regular Price: $2,680.00

Special Price $2,144.00

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Biological Activity

NXT629 is a potent, selective, and competitive PPAR-α antagonist, with an IC50 of 77 nM for human PPARα, shows high selectivity over other nuclear hormone receptor, such as PPARδ, PPARγ, ERβ, GR and TRβ, IC50s are 6.0, 15, 15.2, 32.5 and >100 μM, respectively.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 16.4 mL 82 mL 163.99 mL
0.5 mM 3.28 mL 16.4 mL 32.8 mL
1 mM 1.64 mL 8.2 mL 16.4 mL
5 mM 0.33 mL 1.64 mL 3.28 mL

*The above data is based on the productmolecular weight 609.78. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A18771
Actions Antagonist
CAS No. 1454925-59-7
Formula C35H39N5O3S
M. Wt 609.78
Purity >98%
Synonyms NXT 629, NXT-629
SMILES O=S(C1=CC=CC=C1)(NC2=CC=C(C3=CC=C(CCCC(N4CC)=NN(CC5=CC=C(C(C)(C)C)C=C5)C4=O)C=C3)N=C2)=O
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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