Fig. 1 · Structure
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ω-Agatoxin TK
P/Q Type Ca2+ Channel Blocker
ω-Agatoxin TK is a peptidyl toxin derived from the venom of Agelenopsis aperta, which selectively inhibits P/Q type Ca2+ channels. This compound effectively blocks high potassium-induced calcium influx in cerebral isolated nerve endings, exhibiting an IC50 of 60 nM. ω-Agatoxin TK demonstrates no influence on L-type, N-type, or T-type calcium channels, making it a valuable tool for studying calcium channel physiology and neurotransmitter release mechanisms.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 158484-42-5 |
| Applications | P/Q Type Ca2+ Channel Blocker |
| Formula | C215H337N65O70S10 |
| Molecular Weight | 5273.02 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.