Fig. 1 · Structure
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O-Deshydroxyethyl bosentan
Metabolite of Bosentan
O-Deshydroxyethyl bosentan is a significant metabolite of Bosentan, functioning as a competitive dual antagonist for the endothelin-1 (ET) receptors, ETA and ETB. This compound demonstrates key biological activity in modulating vascular function and can be utilized in research applications focused on cardiovascular diseases and pulmonary hypertension. Its role in endothelin signaling pathways may provide insights into therapeutic interventions and mechanisms of drug action related to Bosentan and its metabolic derivatives.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 174227-14-6 |
| Applications | Metabolite of Bosentan |
| Formula | C25H25N5O5S |
| Molecular Weight | 507.56 |
| SMILES | O=S(C1=CC=C(C(C)(C)C)C=C1)(NC2=NC(C3=NC=CC=N3)=NC(O)=C2OC4=CC=CC=C4OC)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.