Fig. 1 · Structure
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O-Desmethyl apixaban
Apixaban Metabolite
O-Desmethyl apixaban is a metabolite of the anticoagulant apixaban, which functions as a highly selective and reversible inhibitor of Factor Xa, exhibiting a Ki of 0.08 nM in humans and 0.17 nM in rabbits. This compound is essential for studying the pharmacokinetics and pharmacodynamics of apixaban, contributing to research on its anticoagulant activity and safety profiles. Its role in drug metabolism further aids investigations into potential drug interactions and therapeutic outcomes in various cardiovascular conditions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 503612-76-8 |
| Applications | Apixaban Metabolite |
| Formula | C24H23N5O4 |
| Molecular Weight | 445.47 |
| SMILES | O=C(C1=NN(C2=CC=C(O)C=C2)C3=C1CCN(C4=CC=C(N5C(CCCC5)=O)C=C4)C3=O)N |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.