Fig. 1 · Structure
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O-Desmethyl Brinzolamide hydrochloride
Carbonic Anhydrase Inhibitor
O-Desmethyl Brinzolamide hydrochloride is a potent carbonic anhydrase inhibitor, demonstrating a Kd of 0.136 nM for carbonic anhydrase II and an IC50 of 165 nM for carbonic anhydrase IV. This active metabolite of Brinzolamide is essential for research focused on the regulation of bicarbonate ions and pH homeostasis in various biological systems. It holds potential applications in studying conditions driven by abnormal carbonic anhydrase activity, including glaucoma and other metabolic disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2967475-56-3 |
| Applications | Carbonic Anhydrase Inhibitor |
| Formula | C11H20ClN3O5S3 |
| Molecular Weight | 405.94 |
| SMILES | CCN[C@H]1CN(CCCO)S(=O)(C2=C1C=C(S(=O)(N)=O)S2)=O.[H]Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.