O-Desmethyl Brinzolamide hydrochloride is a potent carbonic anhydrase inhibitor, demonstrating a Kd of 0.136 nM for carbonic anhydrase II and an IC50 of 165 nM for carbonic anhydrase IV. This active metabolite of Brinzolamide is essential for research focused on the regulation of bicarbonate ions and pH homeostasis in various biological systems. It holds potential applications in studying conditions driven by abnormal carbonic anhydrase activity, including glaucoma and other metabolic disorders.
O-Desmethyl Brinzolamide hydrochloride is a potent carbonic anhydrase inhibitor, demonstrating a Kd of 0.136 nM for carbonic anhydrase II and an IC50 of 165 nM for carbonic anhydrase IV. This active metabolite of Brinzolamide is essential for research focused on the regulation of bicarbonate ions and pH homeostasis in various biological systems. It holds potential applications in studying conditions driven by abnormal carbonic anhydrase activity, including glaucoma and other metabolic disorders.
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