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O-Desmethyl dacomitinib

Dacomitinib Metabolite

O-Desmethyl dacomitinib is a significant metabolite of dacomitinib, functioning primarily as a pan-epidermal growth factor receptor (ErbB) tyrosine kinase inhibitor. Although it shows lower systemic exposure compared to its parent compound, its biological activity remains relevant for research into tumor biology and cancer therapeutics. O-Desmethyl dacomitinib's formation is closely linked to the enzymatic activity of CYP2D6, making it important for studies involving drug metabolism and pharmacogenomics.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2468202-15-3
Applications	Dacomitinib Metabolite
Formula	C₂₃H₂₃ClFN₅O₂
Molecular Weight	455.91
Synonyms	PF-05199265
SMILES	OC(C(NC(/C=C/CN1CCCCC1)=O)=C2)=CC3=C2C(NC4=CC(Cl)=C(C=C4)F)=NC=N3

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.