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O-Desmethyl Midostaurin-d5

Metabolite of Midostaurin

O-Desmethyl Midostaurin-d5 is a deuterated form of O-Desmethyl PKC412, serving as the active metabolite of Midostaurin, produced through cytochrome P450-mediated liver metabolism. This compound exhibits significant biological activity in regulating protein kinase C (PKC) pathways, making it useful for research focused on cancer therapies and molecular mechanisms of drug action. Its deuterated labeling also enables precise tracking and analysis in metabolic studies.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	2699608-28-9
Applications	Metabolite of Midostaurin
Formula	C₃₄H₂₃D₅N₄O₄
Molecular Weight	561.64
Synonyms	CGP62221-d5; O-Desmethyl PKC412-d5
SMILES	O=C1C2=C(C(C3=C4C=CC=C3)=C5N4[C@]6(O[C@@H](N7C5=C2C8=C7C=CC=C8)C[C@H]([C@H]6O)N(C(C(C([2H])=C9[2H])=C(C([2H])=C9[2H])[2H])=O)C)C)CN1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.