Fig. 1 · Structure
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Octamethylcyclotetrasiloxane
BRCA1 Inhibitor
Octamethylcyclotetrasiloxane functions as a BRCA1 inhibitor, demonstrating the ability to promote anchorage-independent growth in MCF-10A and MCF-10F cell lines. This compound induces DNA damage while simultaneously inhibiting the expression of the DNA-repairing protein BRCA1 with prolonged and high-concentration exposure. Additionally, Octamethylcyclotetrasiloxane exhibits intrinsic estrogenic activity, making it of interest for studies involving hormonal regulation and DNA damage response.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 556-67-2 |
| Applications | BRCA1 Inhibitor |
| Formula | C8H24O4Si4 |
| Molecular Weight | 296.62 |
| SMILES | C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.