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Octinoxate

Ingredient of Sunscreens, Thyroid Hormone Receptor Agonist, ultraviolet filter

Octinoxate (Octyl methoxycinnamate) serves as a thyroid hormone receptor agonist, effectively reducing levels of triiodothyronine (T3) and thyroxine (T4), as well as transcription of genes associated with type II deiodinase (deio2) in Japanese Medaka. It is widely utilized as a safe ultraviolet (UV) filter in sunscreen formulations, offering protection in the aquatic environment. Additionally, Octinoxate modulates hyaluronan (HA) metabolism by inhibiting CYP1A1 and CYP1B1 in a PI3K pathway-dependent manner in human keratinocytes. It also demonstrates anti-estrogenic and anti-androgenic effects in both in vitro and in vivo studies.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Agonist
CAS Number	5466-77-3
Applications	Ingredient of Sunscreens, Thyroid Hormone Receptor Agonist, ultraviolet filter
Formula	C₁₈H₂₆O₃
Molecular Weight	290.40
Synonyms	Octyl methoxycinnamate
SMILES	O=C(OCC(CC)CCCC)/C=C/C1=CC=C(OC)C=C1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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Octinoxate

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Octinoxate 500 mg