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Octyl-α-ketoglutarate

α-ketoglutarate Derivative

Octyl-α-ketoglutarate is a cell-permeable derivative of α-ketoglutarate that acts primarily by enhancing prolyl hydroxylase (PHD) activity. This compound is particularly effective in cells with impaired tricarboxylic acid (TCA) cycle function, such as HEK293 cells, where it stabilizes PHD activity. Additionally, Octyl-α-ketoglutarate serves as a competitive inhibitor of succinate and fumarate, preventing their inhibitory effects on PHD. This makes it a valuable tool for research into metabolic pathways and cellular responses to hypoxia.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	876150-14-0
Applications	α-ketoglutarate Derivative
Formula	C₁₃H₂₂O₅
Molecular Weight	258.31
Synonyms	1-Octyl 2-oxopentanedioate
SMILES	O=C(OCCCCCCCC)C(CCC(O)=O)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.