Odafosfamide is a selective prodrug bis-alkylating agent that is activated by aldehyde-keto reductase 1C3 (AKR1C3). It exhibits potent cytotoxicity in cell lines that express high levels of AKR1C3, demonstrating significant antitumor activity in various cancers, including liver cancer, non-small cell lung cancer, and leukemia. This compound is suitable for use in cancer research to investigate mechanisms of action and therapeutic potential in malignancies characterized by elevated AKR1C3 expression.
Odafosfamide is a selective prodrug bis-alkylating agent that is activated by aldehyde-keto reductase 1C3 (AKR1C3). It exhibits potent cytotoxicity in cell lines that express high levels of AKR1C3, demonstrating significant antitumor activity in various cancers, including liver cancer, non-small cell lung cancer, and leukemia. This compound is suitable for use in cancer research to investigate mechanisms of action and therapeutic potential in malignancies characterized by elevated AKR1C3 expression.
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