Fig. 1 · Structure
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Odevixibat
ASBT Inhibitor
Odevixibat is a selective and orally active inhibitor of the ileal apical sodium-dependent bile acid transporter (ASBT). It has demonstrated efficacy in reducing cholestatic liver and bile duct injury in mouse models. This compound holds potential for the treatment of primary biliary cirrhosis and is valuable for research related to liver diseases and bile acid transport mechanisms.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 501692-44-0 |
| Applications | ASBT Inhibitor |
| Formula | C37H48N4O8S2 |
| Molecular Weight | 740.93 |
| Synonyms | A4250 |
| SMILES | CC[C@H](NC([C@H](NC(COC1=C(SC)C=C(C2=C1)N(C3=CC=CC=C3)CC(CCCC)(CCCC)NS2(=O)=O)=O)C4=CC=C(O)C=C4)=O)C(O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.