ODN 2216 is a selective agonist for human Toll-like receptor 9 (TLR9), known for its role in immune modulation. It stimulates the production of large quantities of interferons, specifically IFN-α and IFN-β, through activation of plasmacytoid dendritic cells (pDCs). ODN 2216 also enhances IL-12 (p40) production by dendritic cells and promotes interferon-gamma (IFN-γ) secretion in peripheral blood mononuclear cells (PBMC) in an indirect manner mediated by IFN-α/β. Additionally, this reagent activates natural killer (NK) cells and supports IFN-γ production in TCR-activated CD4+ T cells, making it valuable for research in immunology and vaccine development.
ODN 2216 is a selective agonist for human Toll-like receptor 9 (TLR9), known for its role in immune modulation. It stimulates the production of large quantities of interferons, specifically IFN-α and IFN-β, through activation of plasmacytoid dendritic cells (pDCs). ODN 2216 also enhances IL-12 (p40) production by dendritic cells and promotes interferon-gamma (IFN-γ) secretion in peripheral blood mononuclear cells (PBMC) in an indirect manner mediated by IFN-α/β. Additionally, this reagent activates natural killer (NK) cells and supports IFN-γ production in TCR-activated CD4+ T cells, making it valuable for research in immunology and vaccine development.
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