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ODN TTAGGG

Catalog No.: A35254
TLR Antagonist
ODN TTAGGG is a TLR9, AIM2, and cGAS antagonist that functions as an inhibitory oligonucleotide. This compound inhibits the activation of the AIM2 inflammasome as well as cGAS by competing with endogenous DNA. As a result, ODN TTAGGG obstructs AIM2-mediated pyroptosis and reduces IL-18 production. Its immunosuppressive properties make it useful in research related to autoimmune diseases, including lupus erythematosus.
ODN TTAGGG 1801724-76-4 TLR Antagonist
Grouped product items
Size Price Stock Qty
1mg
$130.00
In stock
5mg
$360.00
In stock
10mg
$575.00
In stock
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionODN TTAGGG is a TLR9, AIM2, and cGAS antagonist that functions as an inhibitory oligonucleotide. This compound inhibits the activation of the AIM2 inflammasome as well as cGAS by competing with endogenous DNA. As a result, ODN TTAGGG obstructs AIM2-mediated pyroptosis and reduces IL-18 production. Its immunosuppressive properties make it useful in research related to autoimmune diseases, including lupus erythematosus.
Product Information
Catalog NumA35254
Molecular Weight7944.30
CAS Number1801724-76-4
SequenceDNA, d(P-thio)(T-T-A-G-G-G-T-T-A-G-G-G-T-T-A-G-G-G-T-T-A-G-G-G)
SMILES[DNA, d(P-thio)(T-T-A-G-G-G-T-T-A-G-G-G-T-T-A-G-G-G-T-T-A-G-G-G)]
SynonymsODN A151
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Immunology & Inflammation > Toll-like Receptors