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OF-1

Catalog No.: A16000

BRPF1B/BRPF2 bromodomain inhibitor

OF-1

OF-1 Chemical Structure

CAS NO. 19973-83-4

OF-1 is a chemical probe for BRPF bromodomains. OF-1 has been shown to bind to BRPF1B with a KD of 100 nM (ITC), to BRPF2 with a KD of 500 nM (ITC) and to BRPF3 with a KD of 2.4 uM (ITC).

Availability: In stock

Package Price Qty
5 mg
$80.00
10 mg
$120.00
50 mg
$520.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

OF-1 is a chemical probe for BRPF bromodomains. OF-1 has been shown to bind to BRPF1B with a KD of 100 nM (ITC), to BRPF2 with a KD of 500 nM (ITC) and to BRPF3 with a KD of 2.4 uM (ITC).
In vitro (25°C) DMSO Warmed: 72 mg/mL (163.52 mM)
Water Insoluble
Ethanol Insoluble
In vivo 5%DMSO+30%PEG300+5%Tween-80+ddH2O 2 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.71 mL 113.56 mL 227.11 mL
0.5 mM 4.54 mL 22.71 mL 45.42 mL
1 mM 2.27 mL 11.36 mL 22.71 mL
5 mM 0.45 mL 2.27 mL 4.54 mL

*The above data is based on the productmolecular weight 440.31. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A16000
Actions Inhibitor
CAS No. 19973-83-4
Formula C17H18BrN3O4S
M. Wt 440.31
Purity >98%
Synonyms OF1, OF 1
SMILES O=S(C1=CC=C(Br)C=C1C)(NC2=C(OC)C=C(N3C)C(N(C)C3=O)=C2)=O
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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