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Biological Activity
OF-1 is a chemical probe for BRPF bromodomains. OF-1 has been shown to bind to BRPF1B with a KD of 100 nM (ITC), to BRPF2 with a KD of 500 nM (ITC) and to BRPF3 with a KD of 2.4 uM (ITC).
| In vitro (25°C) | DMSO | Warmed: 72 mg/mL (163.52 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 5%DMSO+30%PEG300+5%Tween-80+ddH2O | 2 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 22.71 mL | 113.56 mL | 227.11 mL |
| 0.5 mM | 4.54 mL | 22.71 mL | 45.42 mL |
| 1 mM | 2.27 mL | 11.36 mL | 22.71 mL |
| 5 mM | 0.45 mL | 2.27 mL | 4.54 mL |
*The above data is based on the productmolecular weight 440.31. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A16000 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 19973-83-4 |
| Formula | C17H18BrN3O4S |
| M. Wt | 440.31 |
| Purity | >98% |
| Synonyms | OF1, OF 1 |
| SMILES | O=S(C1=CC=C(Br)C=C1C)(NC2=C(OC)C=C(N3C)C(N(C)C3=O)=C2)=O |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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