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OH14

cFLIP Inhibitor/TRAIL Sensitizer

OH14 is a selective inhibitor of cellular FLICE-like inhibitory protein (cFLIP) that enhances the sensitivity of cells to TNF-related apoptosis-inducing ligand (TRAIL). By specifically binding to the DED1 pocket of cFLIP, OH14 disrupts its interaction with the TRAIL-death-inducing signaling complex, thereby facilitating procaspase-8 activation without affecting its recruitment to FADD. This compound promotes TRAIL-mediated apoptosis and reduces cell viability in breast cancer models. OH14 is applicable in research focused on breast cancer therapeutics.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	1018153-87-1
Applications	cFLIP Inhibitor/TRAIL Sensitizer
Formula	C₁₄H₁₁Cl₂NO₄S
Molecular Weight	360.21
SMILES	CC1=C(C=C(C(S(=O)(NC2=CC=CC=C2C(O)=O)=O)=C1)Cl)Cl

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.