Fig. 1 · Structure
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OICR-8268
DCAF1 ligand
OICR-8268 is a reversible ligand targeting the DCAF1 WDR domain, with a binding affinity (Kd) of 38 nM. It serves as a valuable molecular tool for enabling the development of DCAF1-based PROTACs (proteolysis-targeting chimeras), facilitating targeted protein degradation strategies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Ligand / Binder |
| CAS Number | 3000549-26-5 |
| Applications | DCAF1 ligand |
| Formula | C19H14Cl2F2N4O2 |
| Molecular Weight | 439.24 |
| SMILES | O=C(C1=CNN=C1C2=CC=C(Cl)C=C2F)N[C@H](C3=CC=C(F)C(Cl)=C3)CC(N)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.