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Fig. 1 · Structure
Cat. No.
A14651
CAS No.
465-16-7
Formula
C32H48O9
Mol. Weight
576.72

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Oleandrin

Cat. No. A14651 CAS 465-16-7
Oleandrin is a toxic cardiac glycoside found in oleander.

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Biological Activity

Cellular Effect

Cell Line Activity Value Description Reference
BJ IC50 0.026 μM Cytotoxicity against human BJ cells assessed as reduction in cell viability incubated for 72 hrs by resazurin assay [PMID: 32645647]
BJ IC50 0.026 μM Cytotoxicity against human BJ cells assessed as reduction in cell viability after 72 hrs by resazurin dye based assay [PMID: 31325787]
CCRF-CEM IC50 0.019 μM Cytotoxicity against human CEM cells assessed as reduction in cell viability incubated for 72 hrs by resazurin assay [PMID: 32645647]
CCRF-CEM IC50 0.019 μM Antiproliferative activity against human CEM cells assessed as reduction in cell viability after 72 hrs by resazurin dye based assay [PMID: 31325787]
HEK293 IC50 28 nM Cytotoxicity against HEK293 cells after 72 hrs by fluorescence assay [PMID: 29693393]
HeLa IC50 0.062 μM Cytotoxicity against human HeLa cells assessed as reduction in cell viability incubated for 72 hrs by resazurin assay [PMID: 32645647]
HeLa IC50 0.062 μM Antiproliferative activity against human HeLa cells assessed as reduction in cell viability after 72 hrs by resazurin dye based assay [PMID: 31325787]
HPBALL IC50 14 nM Cytotoxicity against human HPBALL cells after 72 hrs by alamar blue dye based fluorescence assay [PMID: 29693393]
MCF7 IC50 0.033 μM Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 72 hrs by resazurin assay [PMID: 32645647]
MCF7 IC50 0.033 μM Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by resazurin dye based assay [PMID: 31325787]

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Specifications

Manufacturer Adooq Bioscience
CAS Number 465-16-7
Formula C32H48O9
Molecular Weight 576.72
Synonyms Corrigen; Foliandrin; Folinerin; Neriol; Neriolin; Neriostene
SMILES
CC1C(C(CC(O1)OC2CCC3(C(C2)CCC4C3CCC5(C4(CC(C5C6=CC(=O)OC6)OC(=O)C)O)C)C)OC)O

Storage & Solubility

In Vitro Solubility

Reported Solubility

SolventReported Solubility
DMSO 91 mg/mL (157.78 mM)
Water Insoluble
Ethanol 9 mg/mL

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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