Fig. 1 · Structure
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Olezarsen sodium
APOC3 Inhibitor
Olezarsen sodium is an APOC3 inhibitor that functions as a GalNAc-modified antisense oligonucleotide. It binds to APOC3 mRNA, leading to its degradation through ribonuclease H1-mediated sense strand cleavage, which decreases the hepatic synthesis of apolipoprotein C-III. This mechanism results in the reduction of plasma triglycerides, apolipoprotein B, and non-high-density lipoprotein cholesterol levels. Olezarsen sodium is valuable for research into familial chylomicronemia syndrome, hypertriglyceridemia, and atherosclerotic cardiovascular disease.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2298451-31-5 |
| Applications | APOC3 Inhibitor |
| Molecular Weight | 8684.86 (free acid) |
| Synonyms | ISIS 678354 sodium; IONIS-APOCIII-LRx sodium; AKCEA-APOCIII-LRx sodium |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.