Olomoucine is a potent ATP-competitive inhibitor of cyclin-dependent kinases (CDKs) including CDC2/cyclin B, Cdk2/cyclin A, and Cdk2/cyclin E, with IC50 values of 7 μM, as well as CDK/p35 kinase (IC50=3 μM) and ERK1/p44 MAP kinase (IC50=25 μM). By targeting these kinases, Olomoucine effectively regulates cell cycle progression and exhibits antitumor activity against melanin-producing tumor cells. This compound is valuable for research into cell cycle regulation and cancer therapy.
Olomoucine is a potent ATP-competitive inhibitor of cyclin-dependent kinases (CDKs) including CDC2/cyclin B, Cdk2/cyclin A, and Cdk2/cyclin E, with IC50 values of 7 μM, as well as CDK/p35 kinase (IC50=3 μM) and ERK1/p44 MAP kinase (IC50=25 μM). By targeting these kinases, Olomoucine effectively regulates cell cycle progression and exhibits antitumor activity against melanin-producing tumor cells. This compound is valuable for research into cell cycle regulation and cancer therapy.
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