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Omigapil

GAPDH Nitrosylation Inhibitor

Omigapil is a GAPDH nitrosylation inhibitor that demonstrates the ability to counteract Aβ1-42-induced tau acetylation, leading to improvements in memory function and locomotor abilities in animal models. This compound holds promise for research applications in Alzheimer’s disease and offers potential insights into the mechanisms underlying congenital muscular dystrophy (CMD). Additionally, Omigapil features an alkyne moiety, allowing it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions, making it a versatile tool in click chemistry investigations.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	181296-84-4
Applications	GAPDH Nitrosylation Inhibitor
Formula	C₁₉H₁₇NO
Molecular Weight	275.34
Synonyms	CGP3466B free base; TCH346
SMILES	C#CCN(CC1=CC2=C(OC3=C1C=CC=C3)C=CC=C2)C

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.