Fig. 1 · Structure
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Onfasprodil
NR2B NAM
Onfasprodil is a selective negative allosteric modulator (NAM) of the NMDA receptor NR2B subunit. It effectively diminishes the activity of NR2B-containing NMDA receptors, contributing to its rapid antidepressant effects. This compound is primarily utilized in research focused on treatment-resistant depression (TRD).
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Modulator |
| CAS Number | 1892581-29-1 |
| Applications | NR2B NAM |
| Formula | C20H23FN2O3 |
| Molecular Weight | 358.41 |
| Synonyms | MIJ-821 |
| SMILES | O[C@H](C1=CC=C(C=N1)O)CN(C2)C[C@](C3)([H])[C@@]2([H])C[C@H]3OC4=C(C=CC=C4)F |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.