Fig. 1 · Structure
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Orazipone
Small Molecule Immunomodulator
Orazipone is a small molecule immunomodulator known for its potent anti-inflammatory properties. It operates by forming reversible thiol complexes that interact with intracellular signaling proteins and glutathione thiol groups. This compound effectively induces apoptosis in eosinophils and inhibits the activation of inflammatory transcription factors, including NF-kB and STAT 1, thus decreasing inducible iNOS expression and nitric oxide production during inflammatory responses. Additionally, Orazipone reduces NADPH oxidase activity, leading to diminished reactive oxygen species (ROS) production. It also demonstrates protective effects against intestinal radiation injury, making it valuable in research applications focused on inflammation and oxidative stress.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 137109-78-5 |
| Applications | Small Molecule Immunomodulator |
| Formula | C13H14O4S |
| Molecular Weight | 266.31 |
| Synonyms | OR 1384 |
| SMILES | O=C(C)/C(C(C)=O)=C\C1=CC=C(S(=O)(C)=O)C=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.