Fig. 1 · Structure
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Orexin receptor antagonist 2
Orexin Receptor (OX Receptor) Antagonist
Orexin receptor antagonist 2 is a selective antagonist of the orexin receptors (OX receptors), exhibiting potent inhibitory activity with pKis of 7.69 and 9.78. This compound is valuable for research into sleep disorders, particularly insomnia, by providing insights into the modulation of orexin signaling pathways involved in the regulation of arousal and wakefulness.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 1457940-75-8 |
| Applications | Orexin Receptor (OX Receptor) Antagonist |
| Formula | C25H31N5O2 |
| Molecular Weight | 433.55 |
| SMILES | O=C1N(CC2=CNC3=C2C=C(OC)C=C3)CCCC14CCN(C5=NC(C)=CC(C)=N5)CC4 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.