Fig. 1 · Structure
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Orexin receptor antagonist 6
OX1 Antagonist
Orexin receptor antagonist 6 selectively targets the orexin 1 receptor (OX1) with a potent Ki of 8.5 nM and demonstrates more than 1180-fold selectivity for the OX2 receptor. This compound does not elicit conditioned place preference (CPP) or aversive effects and effectively inhibits CPP induced by psychoactive substances. Orexin receptor antagonist 6 is a valuable tool for investigating the role of orexin signaling in neurological diseases and related research applications.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1451412-34-2 |
| Applications | OX1 Antagonist |
| Formula | C29H32F3N3O5 |
| Molecular Weight | 559.58 |
| SMILES | O=C(CN1CCC2=CC(OC)=C(C=C2C1CC3=CC=C(C(OC)=C3)OC)OCC(F)(F)F)NCC4=CC=CN=C4 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.