Orexin receptor antagonist 7 selectively targets the orexin receptor 1 (OX1R) with a Ki value of 4.05 nM, demonstrating potent antagonistic activity. This compound shows negligible affinity for the orexin receptor 2 (OX2R) and minimal binding to opioid receptors (μ, δ, κ) with Ki values exceeding 1,000 nM. Orexin receptor antagonist 7 is suitable for research applications focused on opioid addiction and the elucidation of orexin-related pathways in various physiological and pathological contexts.
Orexin receptor antagonist 7 selectively targets the orexin receptor 1 (OX1R) with a Ki value of 4.05 nM, demonstrating potent antagonistic activity. This compound shows negligible affinity for the orexin receptor 2 (OX2R) and minimal binding to opioid receptors (μ, δ, κ) with Ki values exceeding 1,000 nM. Orexin receptor antagonist 7 is suitable for research applications focused on opioid addiction and the elucidation of orexin-related pathways in various physiological and pathological contexts.
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