Fig. 1 · Structure
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Org 274179-0
TSH Receptor Antagonist
Org 274179-0 is a potent allosteric antagonist of the thyroid-stimulating hormone (TSH) receptor, exhibiting an IC50 in the nanomolar range. This compound effectively inhibits TSH- and TSI-mediated activation of the TSH receptor while minimally affecting TSH potency. Org 274179-0 is valuable for research into Graves' disease (GD) and provides insights into TSH receptor modulation and related pathophysiological mechanisms.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 1421683-12-6 |
| Applications | TSH Receptor Antagonist |
| Formula | C28H27F3N2O2 |
| Molecular Weight | 480.52 |
| SMILES | C[C@]1(C2=CC=CC=C2)C3=CC(NC(CCC4=CC(C(F)(F)F)=CC=C4)=O)=CC=C3N(CC1)C(C)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.