Orphanin FQ(1-11) is a potent agonist of the NOP (nociceptin/orphanin FQ peptide) receptor, with a Ki value of 55 nM. This fragment exhibits selective activity, showing no affinity for μ, δ, κ1, or κ3 opioid receptors (Ki > 1000 nM). Orphanin FQ(1-11) has demonstrated analgesic effects in CD-1 mouse models, making it a valuable tool for studying pain modulation and the nociceptin system in various research applications.
Orphanin FQ(1-11) is a potent agonist of the NOP (nociceptin/orphanin FQ peptide) receptor, with a Ki value of 55 nM. This fragment exhibits selective activity, showing no affinity for μ, δ, κ1, or κ3 opioid receptors (Ki > 1000 nM). Orphanin FQ(1-11) has demonstrated analgesic effects in CD-1 mouse models, making it a valuable tool for studying pain modulation and the nociceptin system in various research applications.
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