Fig. 1 · Structure
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OSI-296
cMET/RON kinases Inhibitor
OSI-296 is a selective inhibitor of cMET and RON kinases, designed for oral administration. This compound demonstrates significant antitumor activity in vivo, particularly in MKN45 tumor xenograft models. Its efficacy and well-tolerated profile make it a valuable tool for research into targeted cancer therapies and the exploration of cMET/RON signaling pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1175296-94-2 |
| Applications | cMET/RON kinases Inhibitor |
| Formula | C21H19Cl2FN4O3 |
| Molecular Weight | 465.30 |
| SMILES | O=C(N)N1CC=C(CC1)C2=COC3=C2C=NC(N)=C3O[C@H](C)C4=C(C=CC(F)=C4Cl)Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.