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Osimertinib dimer

Drug Derivative

Osimertinib dimer is a derivative of Osimertinib, a covalent and mutant-selective inhibitor of the epidermal growth factor receptor (EGFR). It demonstrates potent inhibitory activity with IC50 values of 12 nM against the L858R mutant and 1 nM against the L858R/T790M double mutant. This compound is particularly relevant for overcoming T790M-mediated resistance in lung cancer treatments, making it a valuable tool for research in targeted therapies and cancer biology.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2564638-97-5
Applications	Drug Derivative
Formula	C₅₆H₆₇N₁₄O₄+
Molecular Weight	1000.22
SMILES	O=C(NC1=CC(NC2=NC(C3=CN(C)C4=C3C=CC=C4)=CC=N2)=C(C=C1N(CC[N+](C)(CCC(NC5=CC(NC6=NC(C7=CN(C)C8=C7C=CC=C8)=CC=N6)=C(C=C5N(CCN(C)C)C)OC)=O)C)C)OC)C=C

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.