Fig. 1 · Structure
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Osivelotor
HbS Modulator
Osivelotor is an allosteric modulator of deoxyhemoglobin S (HbS), functioning as a small molecule with oral bioavailability. It enhances the oxygen affinity of HbS while inhibiting polymerization, thereby preventing erythrocyte sickling. This compound is primarily utilized in research related to sickle cell disease (SCD), providing insights into therapeutic strategies for managing this condition.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Modulator |
| CAS Number | 2417955-18-9 |
| Applications | HbS Modulator |
| Formula | C20H22N2O6 |
| Molecular Weight | 386.40 |
| Synonyms | GBT-601; GBT-021601 |
| SMILES | O=C(C1=C(N=CC=C1)CCO)N2[C@@H](COCC2)COC3=C(C(O)=CC=C3)C=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.