Fig. 1 · Structure
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OSu-PEG4-VC-PAB-MMAE
Active Compound
OSu-PEG4-VC-PAB-MMAE is an active compound that serves as a key intermediate in the synthesis of GDP-FAmP4MMAE (Monomethylauristatin E), facilitating site-specific conjugation for GDP labeling. This reagent plays an essential role in antibody-drug conjugate (ADC) development, allowing for precise targeting of cancer cells while minimizing off-target effects. Its application extends to studies in cellular delivery of therapeutic agents, enhancing the effectiveness of targeted therapies in cancer research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 2762518-86-3 |
| Applications | Active Compound |
| Formula | C74H117N11O21 |
| Molecular Weight | 1496.78 |
| SMILES | O[C@@H](C1=CC=CC=C1)[C@@H](C)NC([C@H](C)[C@H]([C@@]2([H])N(CCC2)C(C[C@@H](OC)[C@H]([C@@H](C)CC)N(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)C(OCC3=CC=C(C=C3)NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCOCCOCCOCCOCCC(ON4C(CCC4=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)OC)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.