Fig. 1 · Structure
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Oxazolone
Colitis Inducer
Oxazolone is a potent haptenizing agent primarily targeting colitis induction. It effectively induces both acute and chronic inflammation of the large intestine, facilitating models for the study of colitis. This compound triggers Th1/Th2-dependent immune responses, resulting in significant weight loss and diarrhea. Inflammation elicited by Oxazolone can be attenuated through the use of neutralizing antibodies against IL-4 or TNF-α, or by employing decoy IL-13R2-α-FC proteins.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inducer |
| CAS Number | 15646-46-5 |
| Applications | Colitis Inducer |
| Formula | C12H11NO3 |
| Molecular Weight | 217.22 |
| SMILES | O=C(OC(C1=CC=CC=C1)=N/2)C2=C/OCC |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.