Fig. 1 · Structure
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Oxythiamine chloride hydrochloride
Transketolase Inhibitor
Oxythiamine chloride hydrochloride is a potent transketolase inhibitor that functions as a thiamine antagonist. It disrupts the non-oxidative synthesis of ribose, leading to the induction of cell apoptosis and inhibition of cell proliferation. This compound is utilized in cancer research to explore mechanisms of apoptosis and metabolic pathways associated with tumor growth. Its ability to modulate cellular processes makes it a valuable tool for investigating therapeutic strategies in oncology.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 614-05-1 |
| Applications | Transketolase Inhibitor |
| Formula | C12H17Cl2N3O2S |
| Molecular Weight | 338.25 |
| Synonyms | Hydroxythiamine chloride hydrochloride |
| SMILES | CC1=C(CCO)SC=[N+]1CC2=CN=C(C)NC2=O.Cl.[Cl-] |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.