Documents & Downloads

OZD-MET 01

MET Degrader

OZD-MET 01 is a PROTAC-type MET degrader that utilizes a chaperone-mediated mechanism to induce targeted degradation of the MET protein. It exhibits potent inhibition of cell proliferation in non-small cell lung cancer cell lines H596 and H1437, with IC50 values of 3.07 and 3.5 μM, respectively. This compound serves as a valuable tool for cancer research, particularly in studies investigating MET-targeted therapies and mechanisms of resistance in oncogenic signaling pathways.

Out of Stock

Free Aliquoting for Your Order

Tell us your preferred amount per vial. We’ll confirm the options.

Specifications

Manufacturer	Adooq Bioscience
Actions	Degrader
CAS Number	3048497-38-4
Applications	MET Degrader
Formula	C₄₅H₅₀Cl₂FN₇O₈
Molecular Weight	906.83
SMILES	C[C@@H](OC1=CC(C2=CN(N=C2)C3CCN(C(OCCOCCNC(C4=CC(CN(C(C5=CC(C(C)C)=C(O)C=C5O)=O)C)=CC=C4)=O)=O)CC3)=CN=C1N)C6=C(Cl)C(F)=CC=C6Cl

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.