p,p'-DDD (4,4'-DDD) is an organochlorine insecticide and a significant metabolite of p,p'-DDT, functioning primarily as an agonist of estrogen receptors α and β (ERα and ERβ). This compound has been shown to increase DNA damage, promote apoptosis, and induce necrosis in peripheral blood cells. Additionally, p,p'-DDD stimulates cell proliferation in SKBR3 breast cancer cells and activates the AP-1 transcription factor. Research also indicates that it can reduce sleep durations induced by barbiturates and steroids in rodent models.
p,p'-DDD (4,4'-DDD) is an organochlorine insecticide and a significant metabolite of p,p'-DDT, functioning primarily as an agonist of estrogen receptors α and β (ERα and ERβ). This compound has been shown to increase DNA damage, promote apoptosis, and induce necrosis in peripheral blood cells. Additionally, p,p'-DDD stimulates cell proliferation in SKBR3 breast cancer cells and activates the AP-1 transcription factor. Research also indicates that it can reduce sleep durations induced by barbiturates and steroids in rodent models.
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