P2Y1 Antagonist 4 is a selective antagonist of the P2Y1 receptor, demonstrating significant inhibition of receptor-mediated cytosolic calcium increase (IC50 = 1.95 μM) and platelet aggregation (IC50 = 3.24 μM) induced by ADP in rabbit washed platelets. This compound effectively penetrates the blood-brain barrier and has been shown to upregulate nuclear Nrf2 protein levels in H2O2-treated HT22 cells. Additionally, P2Y1 Antagonist 4 reduces myocardial infarct size in a mouse model of acute myocardial infarction, making it a valuable tool for research in ischemic stroke and myocardial infarction.
P2Y1 Antagonist 4 is a selective antagonist of the P2Y1 receptor, demonstrating significant inhibition of receptor-mediated cytosolic calcium increase (IC50 = 1.95 μM) and platelet aggregation (IC50 = 3.24 μM) induced by ADP in rabbit washed platelets. This compound effectively penetrates the blood-brain barrier and has been shown to upregulate nuclear Nrf2 protein levels in H2O2-treated HT22 cells. Additionally, P2Y1 Antagonist 4 reduces myocardial infarct size in a mouse model of acute myocardial infarction, making it a valuable tool for research in ischemic stroke and myocardial infarction.
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