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P4pal10

PAR4 Antagonist

P4pal10 is a potent antagonist of the protease-activated receptor 4 (PAR4). It effectively inhibits platelet aggregation and tissue factor (TF)-induced thrombin generation, exhibiting significant anticoagulant and antithrombotic properties. Additionally, P4pal10 reduces carrageenan-induced edema and granulocyte infiltration, and demonstrates protective effects in murine models of myocardial ischemia/reperfusion injury. This compound is valuable for research applications focused on thrombotic disorders and cardiovascular protection.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Antagonist
CAS Number	1021346-05-3
Applications	PAR4 Antagonist
Formula	C₆₅H₁₁₂N₂₂O₁₃
Molecular Weight	1409.72
SMILES	[C@@H](CC1=CC=C(O)C=C1)(NC([C@@H](NC([C@@H](NC(CNC([C@@H](NC(CCCCCCCCCCCCCCC)=O)CO)=O)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)C(NCC(N[C@@H](CC2=CN=CN2)C(N[C@H](C(N[C@H](C(N[C@@H](CCCNC(=N)N)C(N)=O)=O)CC(C)C)=O)C)=O)=O)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.