p53 Activator 15 is a novel p53 Y220C activator that functions by enhancing the DNA binding affinity of the mutated p53 protein, with a SC50 value of 0.58 nM. This compound demonstrates significant antiproliferative effects on NUGC-3 gastric cancer cells and effectively inhibits tumor growth in NUGC-3 xenograft models in both mouse and rat systems. p53 Activator 15 serves as a valuable tool for investigating the role of p53 activation in gastric cancer research.
p53 Activator 15 is a novel p53 Y220C activator that functions by enhancing the DNA binding affinity of the mutated p53 protein, with a SC50 value of 0.58 nM. This compound demonstrates significant antiproliferative effects on NUGC-3 gastric cancer cells and effectively inhibits tumor growth in NUGC-3 xenograft models in both mouse and rat systems. p53 Activator 15 serves as a valuable tool for investigating the role of p53 activation in gastric cancer research.
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